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Showing posts from August, 2012

Some Structural Aspects of Non-covalent DNA Binding Agents

Keywords: Drug-DNA binding, DNA intercalation, Minor Groove binding, Drug Design Introduction Cancer is a group of over 100 diseases known by the prolific increase of cellular mass of the tissues in an unusual manner to cause death of a person.1 In addition, cancerous cells do not adhere to each other and to the inter-cellular matrix. This property of non-adherence enables them to propagate to distant sites in the body and spread the cancer.2             Modern day drug discovery is fundamentally driven by biology. Biological molecules like DNA & proteins are valuable targets for drug action. DNA is central to several life processes like replication, transcription, etc. DNA produces copies of itself via replication mechanism. On the other hand, DNA transcription results in the synthesis of proteins. Since DNA is an indispensable part of the living system, it can be a valuable target for drug action.3 With the help of DNA binding drugs, one can target vital processes like replicatio…